Molecular Formula | C14H9Cl3 |
Molar Mass | 283.58 |
Density | 1.360±0.06 g/cm3(Predicted) |
Boling Point | 394.2±42.0 °C(Predicted) |
Storage Condition | -20℃ |
In vitro study | PDM2 (Compound 4b) exhibits a K i of 1.2±0.4 nM for AhR and no affinity for estrogen receptor (ER), confirming that replacement of hydroxyl with chloride abolished binding on ER and increased dramatically the affinity for AhR. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 3.526 ml | 17.632 ml | 35.263 ml |
5 mM | 0.705 ml | 3.526 ml | 7.053 ml |
10 mM | 0.353 ml | 1.763 ml | 3.526 ml |
5 mM | 0.071 ml | 0.353 ml | 0.705 ml |
biological activity | PDM2 is a potent, selective antagonist of aryl hydrogen receptor (AhR). |
Target | Ki: 1.2±0.4 nM(AhR) |